Resident Evil Actor Describes Zach Cregger’s Video Game Adaptation as a “Wild” and “Humorous” Origin Tale

If you found yourself nervously chuckling at how Zach Cregger delivered spine-chilling scares in his previous horror work, then get ready for his upcoming Resident Evil film, which promises to be just as thrilling. In a recent chat, Kali Reis, who stars in the new film Mercy and is also part of the True Detective: Night Country cast, teased what fans can expect as Raccoon City undergoes a fresh take. While the film will prioritize sheer terror, Cregger is also weaving in some humor to balance the horror, even as characters face gruesome fates.

“For Resident Evil fans, especially gamers, his take on an origin story is incredible,” Reis hinted. “You’re going to be amazed by his creativity and the comedic journey he’s crafted through this wild chapter of the Resident Evil saga. I think you’ll be pleasantly surprised.”

What we know about Cregger’s venture into this iconic survival horror franchise is that it will stray from the established lore and beloved characters. Instead, the film will present “an entirely original story,” focusing on a mild-mannered medical courier, played by Austin Abrams, who is tasked with delivering an organ to a hospital when chaos ensues. From there, we can only imagine he’ll be gathering items and strategizing to survive.

Joining Abrams and Reis is an intriguing cast that includes Paul Walter Hauser, Zach Cherry from Severance, and Johnno Wilson, who has experience with video game adaptations from the Twisted Metal series. It’ll be interesting to see who makes it through the chaos when Resident Evil hits theaters on September 18, 2026.